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The excretion of Vincristine can be decreased when combined with Buspirone. In 2007, Health Canada approved duloxetine for the treatment of depression and diabetic peripheral neuropathic pain. There are several types of medications that interact with grapefruit. It works by blocking a certain enzyme (phosphodiesterase-PDE5). Protease inhibitors' metabolic side effects: cholesterol, triglycerides, blood sugar, and "Crix belly "". Drugs for intermittent claudication.