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The incidence of orthostatic effects was reported by one percent of studied patients. It works by increasing bone density and preventing bone breakdown. The risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Betamethasone. The serum concentration of Prucalopride can be increased when it is combined with Doxazosin. Primarily hepatic (mainly cytochrome P450 3A4). The mean (±SD) AUC (0-last) (339±203 ng•hr/mL), C max (102±48 ng/mL) and t 1/2 (3.