- Abihka Alabama
- Adaes - see Adai
- Acolapissa Louisiana
- Adahi - see Adai
- Adai (Adaizan, Adaizi, Adaise, Adahi, Adaes, Adees, Atayos) Louisiana
- Adaise - see Adai
- Adaizan - see Adai
- Adaizi - see Adai
- Adees - see Adai
- Ais Florida
- Akokisa Texas southeast coast
- Alabama Alabama
- Alafay (Alafia, Pojoy, Pohoy, Costas Alafeyes, Alafaya Costas) Florida
- Amacano Florida
- Apalachee Florida
- Apalachicola Georgia, Florida
- Atakapa (Attacapa) Louisiana west coast
- Atayos - see Adai
- Attacapa - see Atakapa
- Avoyel ("little Natchez") northern Texas
- Backhooks Nation (=Pahoc ?) South Carolina
- Bayogoula southeastern Louisiana
- Bidai eastern Texas
- Biloxi Mississippi
- Boca Ratones Florida
- Caddo Arkansas, Louisiana, Oklahoma, Texas
- Calusa Florida
- Cape Fear Indians North Carolina southern coast
- Catawba South Carolina
- Chacato (Chatot, Chactoo) West Florida
- Chawasha
- Cheraw (Chara, Charàh) North Carolina
- Cherokee North Carolina, Eastern Tennessee; later Oklahoma
- Chiaha
- Chickahominy Virginia
- Chickamauga A Branch of Cherokee in Southeastern Tennessee, Northeastern Georgia
- Chickanee (Chiquini) North Carolina
- Chickasaw Mississippi, South Carolina, North Carolina, later Oklahoma
- Chine Florida
- Chisca (Cisca) Florida
- Chitimacha Louisiana
- Choctaw Mississippi, Alabama, and parts of Louisiana; later Oklahoma
- Creek Alabama; Oklahoma, Georgia
- Congaree (Canggaree) South Carolina
- Coree North Carolina
- Coushatta Louisiana
- Coharie North Carolina
- Cusabo coastal South Carolina
- Eno (people) North Carolina
- Eyeish (Hais, Aliche, Aiche) eastern Texas
- Garza Texas, northern Mexico
- Grigra
- Guacata (Santalûces) Florida
- Guacozo Florida
- Guazoco Florida
- Guale (Iguaja, Ybaja) coastal Georgia & Florida
- Hitchiti Georgia, Alabama, Florida
- Hooks Nation (=Huaq ?) South Carolina
- Houma Louisiana
- Iswa
- Jaega Florida
- Jobe (Hobe) Florida, part of Jaega
- Jororo Florida
- Keyauwee North Carolina
- Koasati
- Koroa
- Luca (tribe) Florida
- Lumbee North Carolina
- Manahoac Virginia
- Mattaponi Virginia
- Matecumbe (Matacumbêses, Matacumbe, Matacombe) Florida coast
- Mayaca (tribe) Florida
- Mayaimi Florida
- Mayajuaca Florida
- Meherrin North Carolina
- Mikasuki (Miccosukee) Florida
- Mobila (Mobile, Movila) Alabama, western Florida(?)
- Mocoso Florida
- Monacan Virginia
- Monyton (Moneton, Monekot, Moheton) (Siouan) West Virginia, Virginia
- Mougoulacha southeastern Louisiana
- Nahyssan Virginia
- Naniaba Alabama
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- Nansemond Virginia
- Natchez Mississippi, Louisiana
- Neusiok (Newasiwac, Neuse River Indians) North Carolina
- Nottaway
- Occaneechi (Siouan) Virginia
- Oconee Georgia, Florida
- Ofo
- Okchai (Ogchay)
- Okelousa Louisiana
- Opelousa Louisiana
- Osochee (Oswichee, Usachi, Oosécha)
- Pacara Florida
- Pakana (Pacâni, Pagna, Pasquenan, Pak-ká-na, Pacanas)
- Pamlico (North Carolina)
- Pamunkey Virginia
- Pascagoula Mississippi coast
- Patiri southeastern Texas
- Pee Dee South Carolina, North Carolina
- Pensacola Florida panhandle
- Quinipissa southeastern Louisiana
- Rappahannock Tribe Virginia
- Saluda (Saludee, Saruti) South Carolina
- Santee (Seretee, Sarati, Sati, Sattees) South Carolina (≠Santee Sioux)
- Santa Luces Florida
- Saponi
- Saura North Carolina
- Sawokli (Sawakola, Sabacola, Sabacôla, Savacola) Florida
- Saxapahaw (Sissipahua, Shacioes) North Carolina
- Seminole Florida, Oklahoma
- Sewee (Suye, Joye, Xoye, Soya) South Carolina coast
- Shoccoree (Schockoorees ?) North Carolina (also Virginia?)
- Stegara
- Stuckanox
- Sugeree (Sagarees, Sugaws, Sugar, Succa) South Carolina
- Surruque Florida
- Suteree (Sitteree, Sutarees, Sataree) North Carolina
- Taensa
- Tawasa Virginia
- Tequesta Florida
- Terocodame
- Timucua Florida, Georgia
- Tiou
- Tocaste Florida
- Tocobaga Florida
- Tohomé Alabama
- Tomahitan eastern Tennessee
- Topachula Florida
- Tukabahchee (Tuk-ke-bat-che)
- Tuscarora North Carolina, Virginia (later Niagara Falls, NY)
- Tuskegee
- Tutelo
- Tunica Mississippi
- Utiza Florida
- Vicela Florida
- Viscaynos Florida
- Waccamaw South Carolina
- Wateree (Guatari, Watterees) North Carolina
- Waxhaw (Waxsaws, Wisack, Wisacky, Weesock, Flathead) South Carolina
- Westo Virginia, South Carolina
- Wetumpka (Wee-tam-ka)
- Winyaw South Carolina
- Woccon
- Yamasee Florida, Georgia, South Carolina
- Yazoo
- Yuchi
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