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Over time, the stories she read about her enthusiasm and love of design helped her rethink her career path toward more managerial roles in which she might lead and motivate others. Doxazosin relaxes your veins and arteries so that blood can more easily pass through them. This drug can cause new mental health and behavior problems. The Coxib and traditional NSAID Trialists' Collaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patients. Estrogens can increase the curvature of the cornea and may lead to intolerance of contact lenses. Clinical trials are lacking.