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Women who intend to become pregnant should switch to a different medication if possible, or decrease their dose of valproate. Liver enzymes were shown to increase in activity while oxidants reduced significantly. Although this activity is similar to cyclosporine studies have shown that the incidence of acute rejection is reduced by tacrolimus use over cyclosporine. If you become pregnant while taking this medicine, or are trying to become pregnant, tell your doctor immediately. The therapeutic efficacy of Trichlormethiazide can be decreased when used in combination with Meloxicam. Guess who's Chicago's fastest-growing startup since Groupon".