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Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals". None of the patients treated with ACTOS in the ACTOS controlled clinical trial database to date have had a serum ALT greater than three times the upper limit of the reference range and a corresponding total bilirubin greater than two times the upper limit of the reference range, a combination predictive of the potential for severe drug-induced liver injury. The following year, the Dayton's and Hudson's stores were rebranded under the Marshall Field's name. Take a pill half an hour before you intend to have sexual intercourse. The risk or severity of adverse effects can be increased when Clonidine is combined with Promethazine. Adapalene may increase the nephrotoxic activities of Tacrolimus.