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For people with liver problems: Doxazosin is broken down by your liver. Your blood pressure should be checked regularly. Vardenafil may increase the antihypertensive activities of Valsartan. The therapeutic efficacy of Protein C can be decreased when used in combination with Levonorgestrel. It is important to give the dose immediately after mixing and to be sure the whole amount is taken to be sure the correct dose was given. Adverse reactions reported in ≥5% of the Fortamet ® or immediate-release metformin patients are listed in Table 6.