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Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications (see CONTRAINDICATIONS). Before you start taking Arimidex, tell your doctor if you also take tamoxifen or estrogen. Leydig cell adenomas was observed at 228 times the human exposure (250 mg/kg/day). The risk or severity of adverse effects can be increased when Lithium is combined with Proxibarbal. Manufactured by: Sanofi Winthrop Industrie, Tours, France. Green tea originated in China, but its production and manufacture has spread to many other countries in Asia.