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Use effective birth control to prevent pregnancy while you are using Divigel. When trimethoprim (a dihydrofolate reductase inhibitor) is given with sulfamethoxazole, the sequential blockage of the pathway produced by the two drugs achieves markedly greater inhibition of folic acid synthesis. Cadralazine may increase the hypotensive activities of Nebivolol. Archived from the original on 2014-12-03. Interaction with Clopidogrel: Avoid concomitant use of NEXIUM. The risk or severity of adverse effects can be increased when Metaxalone is combined with Cocaine.