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Very common (10% or more): Nervousness (10. It is usually taken every 4 to 6 hours on a schedule or as needed for pain. Piroxicam is commonly used to manage pain in dogs. One nutrient that can lessen warfarin's effectiveness is vitamin K. The serum concentration of Everolimus can be increased when it is combined with Prednisone. Pregnancy, because there is no reason to use COCs during pregnancy <see>Warnings and Precautions ( 5.