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The risk or severity of adverse effects can be increased when Mefenamic acid is combined with Technetium Tc-99m etidronate. The metabolism of Estradiol valerate can be decreased when combined with Fluvoxamine. Rhodiola also increased the efficiency with which subjects used oxygen, potentially reducing additional stress from oxygen radicals. Tolterodine may increase the QTc-prolonging activities of Granisetron. And guess who her first client is? The mechanism is not clear, but serum lithium concentrations were reduced to 30% of the baseline value in all patients studied, and fell below normal therapeutic ranges.